Protein Details: Aquaporin NIP2-1

Protein ID

ICDB_Pro_1124

Protein Name

Aquaporin NIP2-1

Gene Name

NIP2-1; LSI1; SIIT1; Os02g0745100; LOC_Os02g51110; OJ1118_G04.16; OJ1734_E02.43; OsJ_008085

Organism

Oryza sativa subsp. japonica (Rice)

Length

298 amino acids

AlphaFoldDB

AF-Q6Z2T3-F1-model_v4.pdb

Function

Silicon influx transporter responsible for silicon transport from the external solution to the root cells . Is coupled with the silicon efflux transporter LSI2 in both exodermal and endodermal root cells for an efficient silicon transport across the cells into the stele . Silicon is beneficial to plant growth and helps plants to overcome abiotic and biotic stresses by preventing lodging (falling over) and increasing resistance to pests and diseases; as well as other stresses . Is coupled with LSI2 transporter in roots for efficient uptake of arsenite; which is further dispatched in shoots and grains . Mediates uptake of methylated arsenic species in roots .

Sequence

MASNNSRTNSRANYSNEIHDLSTVQNGTMPTMYYGEKAIADFFPPHLLKKVVSEVVATFLLVFMTCGAAGISGSDLSRISQLGQSIAGGLIVTVMIYAVGHISGAHMNPAVTLAFAVFRHFPWIQVPFYWAAQFTGAICASFVLKAVIHPVDVIGTTTPVGPHWHSLVVEVIVTFNMMFVTLAVATDTRAVGELAGLAVGSAVCITSIFAGAISGGSMNPARTLGPALASNKFDGLWIYFLGPVMGTLSGAWTYTFIRFEDTPKEGSSQKLSSFKLRRLRSQQSIAADDVDEMENIQV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Mainly expressed in the roots. In roots; it localizes in the main and lateral roots; but not in root hairs. Within a root; it localizes on the plasma membrane of the distal side of both exodermis and endodermis; where casparian strips exist (at protein level). Within a root; it localizes on the plasma membrane of the distal side of both exodermis and endodermis; where casparian strips exist (at protein level). Within a root; it localizes on the plasma membrane of the distal side of both exodermis and endodermis; where casparian strips exist (at protein level). Expressed low levels in leaves and anthers

DOI ID

10.1038/nature04590; 10.1038/nature03895; 10.1093/nar/gkm978; 10.1186/1939-8433-6-4; 10.1371/journal.pbio.0030038; 10.1126/science.1081288; 10.1093/pcp/pci172; 10.1038/nature05964; 10.1104/pp.107.107599; 10.1073/pnas.0802361105; 10.1104/pp.109.140350

RefSeq

XP_015626173.1

Feature